Schedules of controlled substances

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  • (a) There are established five schedules of controlled substances, to be known as Schedules I, II, III, IV, and V. Such schedules shall initially consist of the substances listed in this section. The schedules established by this section shall be updated and republished on a semiannual basis during the two-year period beginning one year after the date of enactment of this chapter and shall be updated and republished on an annual basis thereafter.

  • (b) Except where control is required by United States obligations under an international treaty, convention, or protocol, in effect on the effective date of this chapter, and except in the case of an immediate precursor, a drug or other substance may not be placed in any schedule unless the findings required for such schedule are made with respect to such drug or other substance. The findings required for each of the schedules are as follows:

    • (1) Schedule I—

      • (A) The drug or other substance has a high potential for abuse.

      • (B) The drug or other substance has no currently accepted medical use in treatment in the United States.

      • (C) There is a lack of accepted safety for use of the drug or other substance under medical supervision.

    • (2) Schedule II—

      • (A) The drug or other substance has a high potential for abuse.

      • (B) The drug or other substance has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions.

      • (C) Abuse of the drug or other substances may lead to severe psychological or physical dependence.

    • (3) Schedule III—

      • (A) The drug or other substance has a potential for abuse less than the drugs or other substances in schedules I and II.

      • (B) The drug or other substance has a currently accepted medical use in treatment in the United States.

      • (C) Abuse of the drug or other substance may lead to moderate or low physical dependence or high psychological dependence.

    • (4) Schedule IV—

      • (A) The drug or other substance has a low potential for abuse relative to the drugs or other substances in schedule III.

      • (B) The drug or other substance has a currently accepted medical use in treatment in the United States.

      • (C) Abuse of the drug or other substance may lead to limited physical dependence or psychological dependence relative to the drugs or other substances in schedule III.

    • (5) Schedule V—

      • (A) The drug or other substance has a low potential for abuse relative to the drugs or other substance in schedule IV.

      • (B) The drug or other substance has a currently accepted medical use in treatment in the United States.

      • (C) Abuse of the drug or other substance may lead to limited physical dependence or psychological dependence relative to the drugs or other substances in schedule IV.

  • (c) Schedules I, II, III, IV, and V shall, unless and until amended pursuant to section 594, consist of the following drugs or other substances, by whatever official name, common or usual name, chemical name or brand name designated:

      • SCHEDULE I

      • (a) Unless specifically excepted or unless listed in another schedule, any of the following opiates, including their isomers, esters, ethers, salts, and salts of isomers, esters, and ethers, whenever the existence of such isomers, esters, ethers, and salts is possible within the specific chemical designation:

        • (1) Acetylmethadol.

        • (2) Allylprodine.

        • (3) Alphacetylmathadol.

        • (4) Alphameprodine.

        • (5) Alphamethadol.

        • (6) Benzethidine.

        • (7) Betacetylmethadol.

        • (8) Betameprodine.

        • (9) Betamethadol.

        • (10) Betaprodine.

        • (11) Clonitazene.

        • (12) Destromoramide.

        • (13) Dextrorphan.

        • (14) Diampromide.

        • (15) Diethylthiambutene.

        • (16) Dimenoxadol.

        • (17) Dimepheptanol.

        • (18) Dimethylthiambutene.

        • (19) Dioxaphetylbutyrate.

        • (20) Dipipanone.

        • (21) Ethylmethylthiambutene.

        • (22) Etonitazene.

        • (23) Etoxeridine.

        • (24) Furethidine.

        • (25) Hydroxypethidine.

        • (26) Ketobemidone.

        • (27) Levomoramide.

        • (28) Levophenacylmorphan.

        • (29) Morpheridine.

        • (30) Noracymethadol.

        • (31) Norlevorphanol.

        • (32) Normethadone.

        • (33) Norpipanone.

        • (34) Phenampromide.

        • (35) Phenadoxone.

        • (36) Phenomorphan.

        • (37) Phenoperidine.

        • (38) Piritramide.

        • (39) Proheptaxine.

        • (40) Properidine.

        • (41) Racemoramide.

        • (42) Trimeperidine.

      • (b) Unless specifically excepted or unless listed in another schedule, any of the following opium derivatives, their salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation:

        • (1) Acetorphine.

        • (2) Acetyldihydrocodeine.

        • (3) Benzylmorphine.

        • (4) Codeine methylbromide.

        • (5) Codeine-N-Oxide.

        • (6) Cyprenorphine.

        • (7) Desomorphine.

        • (8) Dihydromorphine.

        • (9) Etorphine.

        • (10) Heroin.

        • (11) Hydromorphinol.

        • (12) Methyldesorphine.

        • (13) Methylhydromorphine.

        • (14) Morphine methylbromide.

        • (15) Morphine methylsulfonate.

        • (16) Morphine-N-Oxide.

        • (17) Myrophine.

        • (18) Nicocodeine.

        • (19) Nicomorphine.

        • (20) Normorphine.

        • (21) Pholcodine.

        • (22) Thebacon.

      • (c) Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation, which contains any quantity of the following hallucinogenic substances, or which contains any of their salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation:

        • (1) 3, 4-methylenedioxy amphetamine.

        • (2) 5-methoxy-3, 4-methylenedioxy amphetamine.

        • (3) 3, 4, 5-trimethoxy amphetamine.

        • (4) Bufotenine.

        • (5) Diethyltryptamine.

        • (6) Dimethyltryptamine.

        • (7) 4-methyl-2, 5-dimethoxyamphetamine.

        • (8) Ibogaine.

        • (9) Lysergic acid diethylamide.

        • (10) Cannabis sativa or Marijuana.

        • (11) Synthetic cannabinoids or synthetic marijuana.

        • (12) Mescaline.

        • (13) Peyote.

        • (14) N-ethyl-3-piperidyl benzilate.

        • (15) N-methyl-3-piperidyl benzilate.

        • (16) Psilocybin.

        • (17) Psilocin.

        • (18) Tetrahydrocannabinols.

      • (d) Unless specifically excepted or unless listed in another schedule, any substance that contains any quantity of the following substances, including their salts isomers and salts of isomers, which have a stimulant effect on the central nervous system:

        • (1) 3-Flouromethcathinone.

        • (2) 4-Flouromethacathinone.

        • (3) Mephedrone or 4-methylmethcathinone.

        • (4) 4-methoxymethcathinone.

        • (5) Methylenedioxypyrovalerone (MDPV) or (1-(1,3-Benzodioxol-5-yl)2-(1-pyrrolidinyl)-1-pentanone.

        • (6) Methylone or 3,4-Methylenedioxymethcathinone.

        • (7) 4-Methyl-alpha-pyrrolidinobutiophenone (MPBP).

        • SCHEDULE II

        • (a) Unless specifically excepted or unless listed in another schedule, any of the following substances whether produced directly or indirectly by extraction from substances of vegetable origin, or independently by means of chemical synthesis, or by a combination of extraction and chemical synthesis:

          • (1) Opium and opiate, and any salt, compound, derivative, or preparation of opium or opiate.

          • (2) Any salt, compound, derivative, or preparation thereof which is chemically equivalent or identical with any of the substances referred to in clause (1), except that these substances shall not include the isoquinoline alkaloids of opium.

          • (3) Opium poppy and poppy straw.

          • (4) Coca leaves, and any salt, compound, derivative, or preparation of coca leaves, and any salt, compound, derivative, or preparation thereof which is chemically equivalent or identical with any of these substances, except that the substances shall not include decocainized coca leaves or extraction of coca leaves, which extractions do not contain cocaine or ecgonine.

        • (b) Unless specifically excepted or unless listed in another schedule, any of the following opiates, including their isomers, esters, ethers, salts, and salts of isomers, esters, and ethers, whenever the existence of such isomers, esters, ethers, and salts is possible within the specific chemical designation:

          • (1) Alphaprodine.

          • (2) Anileridine.

          • (3) Bezitramide.

          • (4) Dihydrocodeine.

          • (5) Diphenoxylate.

          • (6) Fentanyl.

          • (7) Isomethadone.

          • (8) Levomethorphan.

          • (9) Levorphanol.

          • (10) Metazocine.

          • (11) Methadone.

          • (12) Methadone-Intermediate, 4-cyano-2-dimethyl-amino-4, 4-diphenyl butane.

          • (13) Moramide-Intermediate, 2-methyl-3-morpholino-1, 1-diphenylpropane-carboxylic acid.

          • (14) Pethidine.

          • (15) Pethidine-Intermediate-A, 4-cyano-1-methyl-4-phenylpiperidine.

          • (16) Pethidine-Intermediate-B, ethyl-4-phenylpiperidine-4-carboxylate.

          • (17) Pethidine-Intermediate-C, 1-methyl-4-phenyl-piperidine-4-carboxylic acid.

          • (18) Phenazocine.

          • (19) Piminodine.

          • (20) Racemethorphan.

          • (21) Racemorphan.

        • (c) Unless specifically excepted or unless listed in another schedule, any injectable liquid which contains any quantity of methamphetamine, including its salts, isomers, and salts of isomers.

          • SCHEDULE III

          • (a) Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances having a stimulant effect on the central nervous system:

            • (1) Amphetamine, its salts, optical isomers, and salts of its optical isomers.

            • (2) Phenmetrazine and its salts.

            • (3) Any substance (except in injectable liquid) which contains any quantity of methamphetamine, including its salts, isomers, and salts of isomers.

            • (4) Methylphenidate.

          • (b) Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances having a depressant effect on the central nervous system:

            • (1) Any substance which contains any quantity of a derivative of barbituric acid, or any salt of a derivative of barbituric acid.

            • (2) Chorhexadol.

            • (3) Glutehimide.

            • (4) Lysergic acid.

            • (5) Lysergic acid amide.

            • (6) Methyprylon.

            • (7) Phencyclidine.

            • (8) Sulfondiethylmethane.

            • (9) Sulfonethylmethane.

            • (10) Sulfonmethane.

          • (c) Nalorphine.

          • (d) Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation containing limited quantities of any of the following narcotic drugs, or any salts thereof:

            • (1) Not more than 1.8 grams of codeine per 100 milliliters or not more than 90 milligrams per dosage unit, with an equal or greater quantity of an isoquinoline alkaloid of opium.

            • (2) Not more than 1.8 grams of codeine per 100 milliliters or not more than 90 milligrams per dosage unit, with one or more active, nonnarcotic ingredients in recognized therapeutic amounts.

            • (3) Not more than 300 milligrams of dihydrocodeinone per 100 milliliters or not more than 15 milligrams per dosage unit, with a fourfold or greater quantity of an isoquinoline alkaloid of opium.

            • (4) Not more than 300 milligrams of dihydrocodeinone per 100 milliliters or not more than 15 milligrams per dosage unit, with one or more active, nonnarcotic ingredients in recognized therapeutic amounts.

            • (5) Not more than 1.8 grams of dihydrocodeine per 100 milliliters or not more than 90 milligrams per dosage unit, with one or more active, nonnarcotic ingredients in recognized therapeutic amounts.

            • (6) Not more than 300 milligrams of ethylmorphine per 100 milliliters or not more than 15 milligrams per dosage unit, with one or more active, nonnarcotic ingredients in recognized therapeutic amounts.

            • (7) Not more than 500 milligrams of opium per 100 milliliters or per 100 grams, or not more than 25 milligrams per dosage unit, with one or more active, nonnarcotic ingredients in recognized therapeutic amounts.

            • (8) Not more than 50 milligrams of morphine per 100 milliliters or per 100 grams with one or more active, nonnarcotic ingredients in recognized therapeutic amounts.

            • SCHEDULE IV

            • (1) Barbital.

            • (2) Chloral betaine.

            • (3) Chloral hydrate.

            • (4) Ethchlorvynol.

            • (5) Ethinamate.

            • (6) Methohexital.

            • (7) Meprobamate.

            • (8) Methylphenobarbital.

            • (9) Paraldehyde.

            • (10) Petrichloral.

            • (11) Phenobarbital.

              • SCHEDULE V Any compound, mixture, or preparation containing any of the following limited quantities of narcotic drugs, which shall include one or more nonnarcotic active medicinal ingredients in sufficient proportion to confer upon the compound, mixture, or preparation valuable medicinal qualities other than those possessed by the narcotic drug alone:

                • (1) Not more than 200 milligrams of codeine per 100 milliliters or per 100 grams.

                • (2) Not more than 100 milligrams of dihydrocodeine per 100 milliliters or per 100 grams.

                • (3) Not more than 100 milligrams of ethylmorphine per 100 milliliters or per 100 grams.

                • (4) Not more than 2.5 milligrams of diphenoxylate and not less than 25 micrograms of atropine sulfate per dosage unit.

                • (5) Not more than 100 milligrams of opium per 100 milliliters or per 100 grams.

        • (d) The Commissioner may by regulation except any compound, mixture or preparation containing any depressant or stimulant substance in paragraph (a) or (b) of schedule III or in schedule IV or V from the application of all or any part of this chapter if (1) the compound, mixture, or preparation contains one or more active medicinal ingredients not having a depressant or stimulant effect on the central nervous system, and (2) such ingredients are included therein such combinations, quantity, proportion, or concentration as to vitiate the potential for abuse of the substances which do have a depressant or stimulant effect on the central nervous system.

    • (e) Any drug not listed in this section which is privately compounded, with specific intent to circumvent the criminal penalties for synthetic cannabinoids or other substances banned in this section, to emulate or simulate the effects of synthetic cannabinoids or other substances banned in this section through chemical changes such as the addition, subtraction or rearranging of radical or the addition, subtraction or rearranging of a substituent, shall be subject to the same criminal penalties as for synthetic cannabinoids or other substances banned in this section.


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