Begin at the Tennessee state line and travel south on U.S. Highway 61 to the intersection of Mississippi Highway 161. Continue on Mississippi Highway 161 to the Town of Walls, Mississippi, and travel south on Old Highway 61 through DeSoto County and Tunica County to the intersection with U.S. Highway 49 near Lula, Mississippi.Continue northwest on U.S. Highway 49 to the intersection with Mississippi Highway 1, and travel south along Mississippi Highway 1.Continue south along Mississippi Highway 1 through Coahoma County, Bolivar County, Washington County, east along Mississippi Highway 1 at Sharkey County and then south along Mississippi Highway 1 at Issaquena County.Continue on Mississippi Highway 1 south to the intersection of U.S. Highway 61 at Mississippi Highway 1 at Onward; continue south along U.S. Highway 61 to the Issaquena/Warren County line.This terminates the "Mississippi Delta Great River Road Scenic Byway."